在患有骨质疏松症患者的MIDLF手术中,经外科手术时使用的Denosumab与双酸盐:短期前性队列研究
Huang Changsheng1, Lei Yue1, Shijun Wang1
1Department of Orthopaedic, Peking University First Hospital, Beijing, China.
Global spine journal
|September 4, 2025
概括
在患有骨质疏松症或骨质疏松症的患者中,外科术前的denosumab和bisphosphonates显著改善了早期的腰部融合率. 与双酸盐相比,德诺苏马布的副作用较少,例如发烧.
科学领域:
- 骨科手术
- 药理学
- 骨质新陈代谢
背景情况:
- 骨质疏松症和骨质疏松症会增加骨折的风险,并且可能会影响脊髓融合后的骨愈合.
- 中线腰部融合 (MIDLF) 手术需要足够的骨融合才能取得成功.
- 对于接受MIDLF的患者来说,优化外科骨健康至关重要.
研究的目的:
- 为了比较denosumab,双酸盐和对照剂在MIDLF后促进腰部融合的疗效和安全性.
- 评估这些治疗对骨代谢标志物和不良事件的影响.
- 为MIDLF患者确定最佳的外科骨质疏松治疗方法.
主要方法:
- 这项前性队列研究涉及54名接受MIDLF治疗的骨质疏松症/ 骨质疏松症患者.
- 患者被分配到德诺苏马布,双酸盐或对照 (+维生素D) 组.
- 评估结果包括融合率,临床评分,骨标志物和6个月的不良事件以及最终的随访.
主要成果:
- 在6个月后,与对照组相比,在denosumab和bisphosphonate组中观察到显著更高的融合率 (P < 0. 001).
- 在denosumab和bisphosphonate组之间没有发现明显的融合率差异.
- 术后发烧在双酸盐组 (71. 4%) 与登苏马布 (11. 8%) 和对照组 (23. 5%) 相比较频繁.
结论:
- 在MIDLF手术后,denosumab和bisphosphonates都有效地提高了早期骨融合率.
- 德诺苏马布具有良好的安全性,术后发烧的发生率较低.
- 在MIDLF患者中,denosumab是推用于治疗骨质疏松症的外科选择.
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