基于NHANES数据 (2001-2018) 的系统性免疫炎症指数与女性乳腺癌之间的关联:横截面研究
Juan Xiong1,2,3, Deju Zhang2,3, Ying Yuan3
1Department of Family Medicine, The Second People's Hospital of Deyang, Deyang, Sichuan, China.
PloS one
|September 4, 2025
概括
系统性免疫炎症指数 (SII) 与女性乳腺癌 (FBC) 患病率呈正相关性. 较高的SII水平表明FBC的概率增加,表明SII是早期查的潜在生物标志物.
科学领域:
- 癌症学
- 免疫学
- 公共卫生
背景情况:
- 乳腺癌是全球女性的主要死亡原因.
- 系统性免疫炎症指数 (SII) 是一种具有各种疾病预后价值的全身炎症指标.
- 之前没有确定SII与女性乳腺癌 (FBC) 风险之间的关联.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 与女性乳腺癌 (FBC) 患病率之间的相关性.
- 评估SII对FBC的诊断和预测能力.
- 探索SII作为FBC查和个性化治疗的生物标志物的潜力.
主要方法:
- 从2001-2018年国家健康和营养检查调查 (NHANES) 的数据分析.
- 应用多变量逻辑回归,AIC,BIC用于模型评估,并调整曲线.
- 进行了子组分析和相互作用测试以验证相关性的稳定性.
主要成果:
- 在17,044名参与者中发现了SII和FBC患病率之间的显著正相关性.
- 每增加100个单位的SII与FBC几率增加3%有关 (OR=1. 03).
- 与最低四分位数相比,SII四分位数最高的人患FBC的几率高出44% (OR=1. 44).
- SII对FBC的诊断能力很好 (AUC=0. 816),与NLR和中性粒细胞数量相当.
结论:
- 系统性免疫炎症指数 (SII) 是与女性乳腺癌患病率相关的有希望的生物标志物.
- 在FBC早期查和个性化治疗策略方面,SII可能提供有价值的见解.
- 需要进一步的研究来阐明SII在FBC管理中的潜在机制和临床效用.
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