"柔性"的集体行为
Philipp W A Schönhöfer1, Sharon C Glotzer1,2
1Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109.
概括
合成的活性微粒,称为柔性,模仿生物细胞. 它们在碰撞时的形状变化导致集体行为如自发流动,
科学领域:
- 软物质物理
- 活性物质系统
- 体科学
背景情况:
- 合成活性微粒越来越多地模仿生物对应物.
- 了解微观系统中的自主行为仍然是一个挑战.
- 弥合合成和生物活性物质之间的差距至关重要.
研究的目的:
- 模拟和研究一个可变形的细胞复合粒子,称为"柔性".
- 使用模拟来探索密集的柔性系统的集体行为.
- 了解粒子的可变性如何影响活性物质的动态.
主要方法:
- 开发一个3D可变形的细胞复合粒子模型 (柔性).
- 在灵活的囊泡中加入自行推进的棒状合体.
- 使用分子动力学模拟来研究柔性系统.
主要成果:
- 在粒子相互碰撞时,柔性体呈现出形状变化,改变了内部棒动态.
- 碰撞诱导的形状变形导致了较慢的柔性运动.
- 观察到运动诱导的相分离和自发的集体流现象.
- 在密集组织中表现出类似细胞迁移的新兴行为.
结论:
- 柔性变形是活性物质中出现集体行为的关键.
- 这些发现为设计响应性,类似细胞的活性粒子提供了基础.
- 在微型/体尺度上控制群体迁移和自主行为的潜力.
相关概念视频
Cell Motility through Blebbing
2.0K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
2.0K
Mechanism of Filopodia Formation
2.5K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.5K
Fascicle Arrangement in Skeletal Muscles
2.4K
Fascicles are bundles of muscle fibers in a skeletal muscle. Muscle fascicle arrangement is directly associated with the power and range of motion of various muscles. The configuration of these fascicles can vary, leading to different functional outcomes.
The four primary types of muscle based on fascicle arrangement are:
The four primary types of muscle based on fascicle arrangement are:
2.4K
Actin Polymerization and Cell Motility
5.4K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.4K
Structure and Organization of Smooth Muscles
6.1K
Smooth muscle tissue is a type of muscle tissue that can be found lining various vital organs in the human body, including the lungs, blood vessels, digestive tract, and respiratory tract. This type of tissue is responsible for regulating the movements of these organs, playing crucial roles in the functioning of various systems, including the vascular, digestive, respiratory, and urinary systems.
Structure of smooth muscle cell
Smooth muscle cells are spindle-shaped with tapering ends and a...
Structure of smooth muscle cell
Smooth muscle cells are spindle-shaped with tapering ends and a...
6.1K
The Role of Actin and Myosin in Non-muscle Cells
3.6K
Actin and myosin or actomyosin filaments also play a significant role in cells other than those involved in muscle contraction (which occurs within the sarcomere of muscle cells). The mechanism of non-muscle cell contractile bundles was first observed in Dictyostelium and Acanthamoeba. In non-muscle cells, two bundles are commonly found: stress fibers and actomyosin adherence belts. These contractile bundles are smaller and less organized than the ones found in muscle cells. They are held...
3.6K


