培根衍生的免疫调节活性:针对循环胺介导的免疫失调
Dingwei Zheng1,2, Caiyun Li1,2, Sangcheng Ni1,2
1National Key Laboratory for Development and Utilization of Forest Food Resources, Zhejiang A&F University, Hangzhou 311300, China.
Journal of agricultural and food chemistry
|September 4, 2025
概括
坚果RWEF,LWPL和FLLR显示出在免疫抑制小鼠中恢复免疫功能的潜力. 它们改善了免疫器官健康,细胞反应和有益的肠道细菌,
科学领域:
- 食品科学与营养
- 免疫学
- 微生物组研究
背景情况:
- (Carya illinoensis) 的生物活性具有免疫调节性质.
- 环胺 (CTX) 是一种常见的诱导免疫抑制的化疗剂.
- 了解免疫恢复的自然化合物对于治疗发展至关重要.
研究的目的:
- 识别和描述具有免疫调节作用的核桃.
- 评估已识别的核桃 (RWEF,LWPL,FLLR) 在小鼠中缓解CTX诱导的免疫抑制的疗效.
- 研究这些对免疫器官指数,细胞免疫力和肠道微生物组合的影响.
主要方法:
- 鉴定和分离三种特定的 (RWEF,LWPL,FLLR) 从北瓜.
- 使用环胺诱导小鼠的免疫抑制.
- 对和胸腺指数,血清生物标志物 (ACP,LDH),血细胞计数,细胞因子,巨细胞和肠道微生物组合的影响进行评估.
主要成果:
- 在免疫抑制小鼠中,花生治疗显著恢复了免疫器官指数和正常化血细胞数量.
- RWEF,LWPL和FLLR显著增加了酸酸酶 (ACP) 和乳酸脱酶 (LDH) 的水平.
- 增强了T细胞免疫力,促进了巨细胞消化,调节了肠道微生物群,丰富了Lachnospiraceae和Eisenbergiella.
结论:
- 来自的可以有效地减轻环胺诱导的免疫抑制.
- 这些通过调节免疫器官功能,细胞免疫反应和肠道微生物组来发挥作用.
- 坚果对恢复免疫系统具有显著的治疗潜力.
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