适应瘤微环境的CA@ZIF-8/MnO2纳米反应器用于自强化级联化学动力学治疗和免疫调节
Yawei Li1, Xialin Sun1, Yilin Huang1
1Jilin Medical University, Jilin 132013, PR China.
Colloids and surfaces. B, Biointerfaces
|September 4, 2025
概括
这项研究引入了CZM纳米粒子,通过增加过氧化和减少谷来增强化学动力疗法 (CDT). 这些纳米颗粒强化基生成以改善抗瘤免疫力和免疫反应.
科学领域:
- 生物医学工程
- 纳米技术
- 癌症治疗
背景情况:
- 由于内过氧化 (H2O2) 和谷氨 (GSH) 吸收率较低,化学动力学治疗 (CDT) 面临限制.
- 现有的CDT策略需要改进以获得有效的临床转化.
研究的目的:
- 开发一种适应瘤微环境 (TME) 的纳米反应器 (CA@ZIF-8/MnO2,CZM) 用于级联放大CDT.
- 为了克服H2O2缺乏和TME中的GSH介导的清理.
- 通过多功能纳米平台增强抗瘤效果和免疫反应.
主要方法:
- 在ZIF-8和MnO2外中整合酸 (CA) 的CZM纳米颗粒的制造.
- 在H2O2生成,GSH耗尽和基 (•OH) 生产中CZM纳米颗粒的体外和体内评价.
- 通过RNA-seq和途径分析评估CZM对免疫细胞死亡 (ICD),巨分化和抗瘤免疫的影响.
主要成果:
- CZM纳米粒子有效地耗尽了GSH,产生了Mn2+催化剂并增强了OH生成.
- 在酸性TME自我放大H2O2水平中释放CA,创建一个正反循环.
- CZM治疗诱导了ICD,促进了M1巨分离,并调节了NF-κB通路,增强了抗瘤免疫力.
结论:
- CZM纳米粒子代表了级增强CDT的一个有前途的多功能平台.
- 开发的纳米反应器有效地重塑免疫抑制TME并增强抗瘤免疫反应.
- 在癌症治疗和免疫治疗中,CZM具有潜力.
相关概念视频
02:17The Tumor Microenvironment
6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
01:27Tumor Immunotherapy
658
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
658
02:49Cancer Therapies
7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K