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通过综合虚拟查和质谱蛋白学来确定针对YAP-TEAD接口3的pyrazolo-piperidinone衍生物作为抗癌剂

Laura Scalvini1, Lorenzo Tagliazucchi2, Gian Marco Elisi1

  • 1Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, I, 43124, Parma, Italy.

European journal of medicinal chemistry
|September 4, 2025
PubMed
概括

研究人员发现了破坏YAP:TEAD复合物的新型pyrazolo-piperidinone化合物,为结直肠和卵巢癌提供了新的抗癌策略,包括耐药类型.

关键词:
抗癌药物光异质性美国的蛋白质组学表型查皮拉佐洛-皮皮里丁衍生物针对 TEAD 的目标

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