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Updated: Sep 9, 2025

Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
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哺乳动物大脑内体质积的细胞类型特异性丰富

Eran A Mukamel1, Hanqing Liu2, M Margarita Behrens3

  • 1Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, USA.

Neuron
|September 4, 2025
PubMed
概括

大脑中的体质马赛克包括染色体变化. 研究人员发现16号染色体与人类21号染色体相似, 在特定的小鼠大脑细胞中被丰富,

关键词:
DNA 甲基化唐氏综合症没有化大脑马赛克主义一个老鼠神经元一个单元身体突变三体症

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Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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