上部胃肠癌患者的非药物干预:系统性审查和分析
Lijun Li1, Shuman Wang1, Qian Sun2
1School of Psychological Sciences, Monash University, Melbourne, Australia.
Journal of pain and symptom management
|September 4, 2025
概括
非药物干预 (NPI) 在改善上胃肠癌患者的睡眠方面具有前景. 心理,信息,症状管理和基于感官的干预措施最有效,尽管需要更多的研究.
科学领域:
- 癌症学
- 睡眠医学
- 基于证据的实践
背景情况:
- 在被诊断为上胃肠癌的患者中,睡眠障碍很普遍.
- 识别有效的,基于证据的干预措施对于管理这一群体的睡眠问题至关重要.
研究的目的:
- 对患上上肠道癌患者的睡眠障碍进行非药物干预措施 (NPI) 的有效性进行系统审查和元分析.
- 确定哪些类型的NPI显示出最显著的睡眠质量改善.
主要方法:
- 包括随机对照试验 (RCT) 和准实验试验在内的六个数据库进行了全面搜索,截至2025年7月.
- 用一个随机效应模型进行元分析,计算标准化平均差异 (SMD) 聚合治疗效应.
- 使用Cochrane偏差风险工具 (RoB2) 和GRADE评分来评估研究质量和偏差风险.
主要成果:
- 分析了涉及2693名参与者的28项研究,显示NPI的整体效果大小 (SMD=-1.18).
- 心理,信息和症状管理干预措施 (SMD=-1.85) 和基于感官的干预措施 (SMD=-1.66) 显示了睡眠的统计显著改善.
- 在这次元分析中,身体活动/康复和营养支持干预措施没有产生统计学上显著的睡眠改善.
结论:
- 虽然NPI显示了改善上部肠道癌症患者睡眠的潜力,但异质性和偏差风险限制了最终的建议.
- 心理和基于感官的干预似乎是最有希望的,但需要进一步进行高质量的大规模随机试验.
- 未来的研究应侧重于强大的方法,以确定这种患者群体的最佳睡眠干预措施.
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