类似的结果,不同的时间:在试管婴儿中,乳腺与卵泡刺激
Barbara Lawrenz1, Sara Peralta2, Erkan Kalafat3
1ART Fertility Clinic, Royal Marina Village, B22-23, Abu Dhabi, UAE; Reproductive Unit, UZ Ghent, Ghent, Belgium.
Fertility and sterility
|September 4, 2025
概括
与卵泡期相比,乳腺期的卵巢刺激不会对胚胎的质量产生负面影响. 这种方法为在生育治疗中面临时间限制的夫妇提供了灵活性.
科学领域:
- 生殖内分泌学
- 辅助生殖技术 (ART)
- 胚胎学
背景情况:
- 卵巢刺激是辅助生殖技术的基石.
- 卵巢刺激开始的时间 (卵泡相对质阶段) 可能会影响结果.
- 了解质期刺激对胚胎发育的影响对于优化生育治疗至关重要.
研究的目的:
- 为了比较质期卵巢刺激与卵泡期刺激对关键IVF结果的影响.
- 具体评估对胚胎数量,胚胎状况和整体胚胎质量的影响.
- 与常规的毛囊阶段刺激相比,确定质阶段刺激是否有任何优点或缺点.
主要方法:
- 追溯队列研究分析了3524个卵泡阶段和552个卵泡阶段的卵巢刺激周期.
- 使用倾向分数匹配 (2:1比) 来控制年龄,BMI和AMH等混变量.
- 对147名女性进行了对分析,这些妇女在一年内经历了白细胞和卵泡阶段周期.
主要成果:
- 流体期刺激周期显著延长,需要更高的淋巴激素剂量.
- 在调整后,两组之间没有观察到成熟卵细胞,总胚胎细胞,活检胚胎细胞或euploid胚胎细胞数量的显著差异.
- 胚胎质量分布 (顶级,良好,公平,差) 在质阶段和卵泡阶段刺激组之间没有显著的变化.
结论:
- 在黄质期开始卵巢刺激不会对胚胎的产卵性或质量产生不利影响.
- 质阶段刺激提供了一个有价值的替代方案,特别是对于时间有限的患者.
- 这种方法扩大了计划生育治疗的灵活性,而不会影响生殖潜力.
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