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Updated: Sep 9, 2025

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对沙特阿拉伯登革热病毒的重复引入和神秘传播的分子进化见解

Muhammad Bashir Bello¹, Zainab BuAli¹, Nidia S Trovao²

¹Infectious Disease Research Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University of Health Sciences, Ministry of National Guard Health Affairs, Riyadh 11426, Saudi Arabia.

The Journal of infection

|September 4, 2025

概括

这项研究揭示了沙特阿拉伯的登革热病毒 (DENV) 共同流通,其中DENV-2占主导地位. 来自南亚和东非的多个介绍强调了加强基因组监测和病媒控制的需要.

科学领域:

* 病毒学和分子流行病学
* 公共卫生和传染病动态
* 病毒病原体的基因组监测

背景情况:

在全球范围内,登革热病毒 (DENV) 构成重大公共卫生威胁.
了解DENV的遗传多样性和传播对于有效的控制至关重要.
沙特阿拉伯独特的人口和地理因素影响着树冠病毒的传播.

研究的目的:

调查沙特阿拉伯DENV菌株的遗传多样性.
* 阐明循环DENV的进化动态和语言地理.
* 确定DENV在该地区的起源和引入途径.

主要方法:

* 在2021-2023年期间收集的DENV菌株的血清定型和全基因组测序.
*使用贝叶斯推断方法进行植物地理分析.
* 遗传重建以估计最近的共同祖先 (TMRCA) 的时间.

主要成果:

* DENV-1,DENV-2和DENV-3的同时循环,其中DENV-2是主要的血清型.
*鉴定出至少5种来自南亚 (印度,斯里兰卡,巴基斯坦) 的DENV-2基因型II.
*从吉布提重新出现DENV-1基因型III,以及从东南亚/印度引入的DENV-3基因型III,有长期未被发现的循环证据.

结论:

沙特阿拉伯是DENV传输的重要区域枢纽.
大众聚会和劳动力迁移是DENV引入和传播的关键因素.
* 加强基因组监测,媒介控制和区域数据共享对于改善疫情准备至关重要.

关键词:

登革热病毒基因组监测植物地理学沙特阿拉伯血清定型

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