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Updated: Sep 9, 2025

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基于蛋白质代谢分析的甲诱导的肝毒性

Sanjita Paudel1, Hyunchae Sim2, Eunjoo Kang2

  • 1College of Pharmacy, Kyungpook National University, Daegu 41566, Republic of Korea.

Toxicology letters
|September 4, 2025
PubMed
概括

甲 (FA) 通过细胞死亡途径铁死导致肝脏损伤. 这项研究确定了STAT3/HO-1生物标志物,并强调了FA诱导的肝毒性中的铁排放.

关键词:
甲肝毒性整合性经济学蛋白质代谢学

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Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation01:22

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
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