恩西特利维尔可以抑制因SARS-CoV-2感染而导致的长期嗅觉异常
Ryoichi Tashima1, Takayuki Kuroda1, Haruaki Nobori1
1Pharmaceutical Research Division, Shionogi & Co., Ltd., 1-1, Futaba-cho 3-chome, Toyonaka, Osaka 561-0825, Japan.
Antiviral research
|September 4, 2025
概括
汉姆斯特在感染SARS-CoV-2后接受恩西特利维尔治疗,可以减少炎症和改善气味. 这表明早期干预可以预防由慢性鼻炎引起的长期嗅觉障碍.
科学领域:
- 病毒学
- 免疫学
- 药理学
背景情况:
- 尽管病毒清除,但2019年新冠病毒病 (COVID-19) 后症状,包括嗅觉障碍仍然存在.
- 这些长期症状的确切机制以及恩西特利维尔如何缓解这些症状仍然不清楚.
研究的目的:
- 使用仓鼠模型调查COVID-19后嗅觉功能障碍的发病原因.
- 阐明恩西特利维尔抑制嗅觉障碍的机制.
主要方法:
- 在最初感染一个月后建立了SARS-CoV-2后感染的仓鼠模型.
- 用恩西特雷尔维尔治疗了仓鼠,并评估了包括体重,病毒RNA水平,嗅觉功能和鼻炎症标记在内的结果.
主要成果:
- 治疗Ensitrelvir导致加速体重恢复,抑制病毒RNA,改善嗅觉.
- SARS-CoV-2 感染与鼻的炎症标志物增加有关,而这些标志物被 ensitrelvir 降低.
- 在嗅觉功能和鼻炎标志物之间发现了正相关性.
结论:
- 在SARS-CoV-2感染后,鼻的慢性炎症可能是持续的气味障碍的基础.
- 早期使用能抑制这种炎症并防止嗅觉功能障碍的出现.
- 恩西特雷尔维尔在COVID-19后具有缓解长期嗅觉缺陷的治疗作用.
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