大脑动态活动和甲状腺失调在MDD的自杀念头
Shuai Zhao1, Anzhen Wang1, Yuqin Han1
1School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230022, China; Affiliated Psychological Hospital of Anhui Medical University, Hefei, 230022, China; Hefei Fourth People's Hospital, Hefei, China.
Journal of affective disorders
|September 4, 2025
概括
患有严重抑郁症和自杀念头的患者表现出甲状腺功能变化和脑部关键情绪控制区域的活动减少. 甲状腺激素水平与大脑活动模式相关,
科学领域:
- 神经科学
- 内分泌学
- 精神病学
背景情况:
- 大型抑郁症 (MDD) 中的自杀念头与甲状腺功能障碍和大脑活动的改变有关.
- 在MDD与SI中甲状腺功能与神经动态之间的精确相互作用需要进一步研究.
研究的目的:
- 在患有 (SI-MDD) 和没有自杀念头 (nSI-MDD) 的MDD患者和健康对照者之间比较甲状腺功能和动态大脑活动 (dALFF).
- 探索甲状腺生物标志物与神经活动之间的关系.
主要方法:
- 对210名MDD患者和103名健康对照进行了甲状腺功能测试和功能磁共振成像 (fMRI).
- 计算了低频波动的动态幅度 (dALFF),以评估神经活动模式.
- 通过一向ANCOVA和后期测试发现了群体差异.
主要成果:
- 与nSI- MDD和健康对照患者相比,SI- MDD患者的TSH水平较高,T3水平较低.
- 在SI-MDD患者中,右侧轨道前下 (R.Orb.IFG) 和右侧前皮层 (R.ACC) 观察到dALFF的减少.
- T3水平与R.Orb.IFG dALFF正相关,而TSH水平与R.ACC dALFF负相关.
结论:
- 甲状腺功能障碍与MDD患者与情绪和认知控制相关的特定区域的大脑活动发生变化有关.
- 甲状腺生物标志物可以提供有关MDD自杀意念的神经生物学机制的见解.
- 需要进一步的研究来验证这些发现并探索临床应用.
相关概念视频
Depression: Overview
331
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
331
Depressive Disorders: Etiology
165
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
165
Bipolar Disorder
142
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
142
Synthesis and Regulation of Thyroid Hormones
5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
Brain Imaging
308
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
308
Depressive Disorders: MDD and Dysthymia
207
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
207


