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糖尿病患者的肺移植:一个系统性审查

Fatemeh Moosaie¹, Shiva Abedinzadeh¹, Sepide Javankiani²

¹International Surgical Research Association (ISRA), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Psychosomatic medicine research center, Imam Khomeini Hospital Complex, Tehran university of medical sciences, Tehran, Iran.

Transplant immunology

|September 4, 2025

概括

糖尿病可显著恶化肺移植的结果,增加死亡率和并发症,不论发病时间如何. 谨慎的血糖管理和监测对于改善这些患者的存活率至关重要.

科学领域:

移植医学
内分泌学
肺病学

背景情况:

肺移植 (LTx) 的存活率落后于其他固体器官.
糖尿病 (DM) 在接受LTx患者中普遍存在,并影响结果.
了解DM对LTx的影响对于改善患者存活率至关重要.

研究的目的:

系统地审查DM对LTx结果的影响.
评估糖尿病发病时间对LTx存活时间的影响.

主要方法:

在2024年12月进行系统的文献搜索 (PubMed,Scopus,Web of Science).
包括LTx患者或正在等待LTx和DM的原始研究和病例系列.
使用非随机研究方法指数 (MINORS) 进行质量评估.

主要成果:

84项研究 (1992 - 2024) 分析了患有DM的LTx患者 (8 - 56%).
糖尿病 (已存在的,CFRD,NODAT) 增加了感染,AKI,血栓栓塞,CLAD和心血管事件的风险.
糖尿病与较高的死亡率,呼吸时间延长和住院病例增加有着一致的相关性.

结论:

糖尿病,前或后LTx,预测不良结果和死亡率.
术前血糖控制,定制免疫抑制和监测至关重要.
需要进行标准化的前性研究,以便在LTx患者中进行最佳的DM治疗.

关键词:

葡萄糖类糖尿病肺移植死亡率术后并发症生存情况

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