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Updated: Sep 9, 2025

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胎盘Igf1过度表达对小鼠胎盘结构产生性别特异的影响,改变后代的纹状发育和行为

Annemarie J Carver1, Faith M Fairbairn2, Robert J Taylor2

  • 1Interdisciplinary Graduate Program in Genetics, University of Iowa, IA, USA; Department of Psychiatry, Carver College of Medicine, University of Iowa, IA, USA; Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, IA, USA.

Experimental neurology
|September 4, 2025
PubMed
概括

胎儿胰岛素样生长因子1 (IGF1) 的过度表达会影响胎儿大脑的发育,特别是纹状体. 这项研究揭示了与疾病相关的神经发育的性别特异性影响.

关键词:
关于CRISPR的研究胰岛素类生长因子1神经发育神经发育障碍胎盘体

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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