通过具有多个基结合部分的粘合单体改善牙结合
Denghao Fu1, Jonathan Hardy2, Caroline R Szczepanski1
1Department of Chemical Engineering & Materials Science, Michigan State University, East Lansing, MI 48824, USA.
Acta biomaterialia
|September 4, 2025
概括
将2-ureido-4[1H]-pyrimidinone (UPy) 单体纳入牙粘合剂可以提高粘合强度和耐久性. UPy功能化甲基胺提高了聚合和生物相容性,UPy-OPG230-MMA在水性条件下表现最佳.
科学领域:
- 生物材料科学
- 聚合物化学
- 牙科材料
背景情况:
- 树脂-牙接口是牙修复中的一个关键弱点,容易降解.
- 由于原体降解和甲酸盐水解,目前的粘合技术难以长期耐用.
- 在接口和粘合树脂内增强结合是一种有前途的策略.
研究的目的:
- 合成和评估UPy功能化的甲胺,以提高牙粘合性能.
- 调查糖醇间隔器灵活性对结合和粘合性能的影响.
- 评估UPy单体对聚合动力学,生物相容性,机械强度和与牙结合的影响.
主要方法:
- 三种基于UPy的甲基胺与不同的糖间隔剂 (UPy-OPG400-MMA,UPy-OPG230-MMA,UPy-OEG148-MMA) 的合成.
- 将UPy单体纳入基于甲酸盐的粘合剂配方.
- 聚合动力学,生物相容性,机械性能和微拉伸键强度 (μTBS) 的评估.
- 使用SEM和拉曼光谱等技术进行界面表征.
主要成果:
- 甲胺增强了聚合动力学,生物相容性和机械性能.
- 糖醇间隔剂的灵活性显著影响了结效率和整体性能.
- 有UPy-OPG230-MMA的树脂在水性条件下表现出最强的结.
- 在自蚀刻粘合剂模型中用UPy-OPG230-MMA取代50%的HEMA,显著改善了μTBS和界面完整性.
结论:
- 具有UPy功能的甲胺为加强牙粘合剂和树脂-牙接口提供了可行的策略.
- UPy-OPG230-MMA单体在水性环境中表现出优异的性能.
- 这种方法提高了粘合剂的耐用性和生物相容性,解决了以前的UPy应用的局限性.
- 开发的UPy单体可在水溶剂中混合,因此适用于牙科应用.
相关概念视频
Hydrogen Bonds
10.2K
A hydrogen bond is formed when a weakly positive hydrogen atom already bonded to one electronegative atom (for example, the oxygen in the water molecule) is attracted to another electronegative atom from another polar molecule, such as water (H2O), hydrogen fluoride (HF), or ammonia (NH3). The huge electronegativity difference between the H atom (2.1) and the atom to which it is bonded (4.0 for an F atom, 3.5 for an O atom, or 3.0 for an N atom), combined with the very small size of an H atom...
10.2K
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)
2.0K
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
2.0K
Complexometric Titration: Ligands
1.1K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
1.1K
Cationic Chain-Growth Polymerization: Mechanism
2.4K
The cationic polymerization mechanism consists of three steps: initiation, propagation, and termination. In the initiation step of the polymerization process, the π bond of a monomer gets protonated by the Lewis acid catalyst, which is formed from boron trifluoride and water. The protonation of the π bond generates a carbocation stabilized by the electron‐donating group. In the propagation step, the π bond of the second monomer acts as a nucleophile and attacks the...
2.4K
Anionic Chain-Growth Polymerization: Overview
2.2K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.2K
Complexation Equilibria: The Chelate Effect
649
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
649


