Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.2K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

12.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K
Autoimmune Disorders01:29

Autoimmune Disorders

666
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
666
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.1K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

28
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
28
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

321
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
321

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Beyond Bioenergetics: Moonlighting Functions of F<sub>1</sub>F<sub>O</sub>-ATPase From ATP Synthesis to an ATP-Wasting Death Switch.

Medicinal research reviews·2026
Same author

Modulation of Mu-Opioid Receptor Expression and Functional Impairment of Natural Killer Cells in Neuropathic Pain: Implications for Biomarker Discovery and Personalized Therapies.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

The Dopaminergic Energy Crisis of Adolescent Depression: Mitochondrial Bioenergetics Control of Nucleus Accumbens Signaling.

Neuroscience bulletin·2026
Same author

A Biphasic Mitochondrial Damage-Management System: The Mitochondrial Derived Vescicles as Yin and Yang.

Journal of biochemical and molecular toxicology·2026
Same author

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum).

Phytotherapy research : PTR·2026
Same author

Mitochondrial dysfunction in cerebrovascular diseases.

Trends in molecular medicine·2026

相关实验视频

Updated: Sep 9, 2025

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry
07:18

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Published on: May 24, 2024

1.2K

主要免疫缺陷疾病,炎症和线粒体功能障碍

Salvatore Nesci1, Francesca Oppedisano2, Giovanni Romeo3

  • 1Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia 40064, Italy.

Clinical immunology (Orlando, Fla.)
|September 4, 2025
PubMed
概括

主要免疫缺陷疾病 (PID) 涉及免疫缺陷和炎症. 线粒体功能障碍将它们联系在一起, 推动疾病并提供新的治疗点.

关键词:
炎症发生线粒体线粒体透性过渡孔主要免疫缺陷疾病它们的 mtDNA

更多相关视频

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

422
Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils
09:39

Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils

Published on: June 2, 2023

2.1K

相关实验视频

Last Updated: Sep 9, 2025

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry
07:18

Author Spotlight: New Insights into PBMC Mitochondrial Responses Using Fluorespirometry

Published on: May 24, 2024

1.2K
Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

422
Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils
09:39

Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils

Published on: June 2, 2023

2.1K

科学领域:

  • 免疫学
  • 线粒体生物学
  • 遗传学

背景情况:

  • 主要免疫缺陷疾病 (PID) 是一种遗传性疾病,导致免疫功能障碍,感染,自身免疫和癌症.
  • 新兴研究揭示了炎症在PID发病过程中的关键作用,

研究的目的:

  • 审查PID中线粒体功能障碍和炎症之间的复杂相互作用.
  • 探索PID的遗传缺陷如何破坏免疫平衡并促进炎症.
  • 突出针对线粒体通路的潜在治疗策略.

主要方法:

  • 对PIDs的遗传缺陷进行文献审查.
  • 分析线粒体功能障碍与炎症相关的机制 (细胞因子失调,氧化应激,炎症酶激活).
  • 在PID病变中探索线粒体通路 (信号,ATP合成酶,mPTP).

主要成果:

  • 在PIDs的遗传缺陷破坏免疫平衡,导致亲炎症状态.
  • 线粒体功能障碍,氧化应激和炎症形成了一个自维持的循环.
  • 线粒体功能受损可能是免疫缺陷和高炎症的关键机制.

结论:

  • 线粒体功能障碍是PID发病的一个关键因素,它将免疫缺陷与炎症联系在一起.
  • 了解这些相互作用为PID机制提供了新的见解.
  • 针对线粒体通路为PID提供了新的治疗机会.