在24个月后,类风湿性关节炎爆发和关节结构变化之间的关联
Bruno Fautrel1, Lisa Bialé2, Marion Couderc3
1Sorbonne Université - Assistance Publique, Pitie Salpetriere University Hospital, Rheumatology department, Paris, France; INSERM UMRS 1136, PEPITES Team, Paris, France; CRI-IMIDIATE Clinical Research Network, Paris, France.
Joint bone spine
|September 4, 2025
概括
风湿性关节炎 (FLARE- RA) 问卷有效地测量了风湿性关节炎 (RA) 疾病活动和患者报告的结果. 然而,它并不能预测 RA 患者的长期关节结构损伤进展.
科学领域:
- 关节病学
- 临床研究
- 患者报告的结果
背景情况:
- 风湿性关节炎 (RA) 的治疗需要精确的疾病活动评估.
- 患者报告的结果测量 (PROM) 对于监测RA越来越重要.
- 自行管理的风湿关节炎爆发评估问卷 (FLARE- RA) 评估了临床访问之间的RA爆发.
研究的目的:
- 要确定FLARE-RA问卷检测到的RA爆发是否预测2年内关节结构损伤的进展.
- 探索FLARE-RA分数与已确定的RA结果指标之间的关联.
主要方法:
- 在221名患有早期关节炎的成年人中进行的前性观察研究 (疾病持续时间<10年,HAQ-DI<1).
- 患者每3个月完成FLARE- RA,每6个月进行24个月的临床随访.
- 在基线和24个月后,对手腕和脚部的X射线图进行了评估.
主要成果:
- 在24个月后,FLARE- RA总分与结构性关节损伤进展或侵蚀进展无关.
- FLARE-RA得分与28个关节的疾病活动得分 (DAS28),医生全球评估和HAQ-DI有显著的相关性.
- FLARE- RA还与患者可接受的症状状态,最小临床重要差异和治疗强化有关.
结论:
- FLARE-RA问卷是评估患者报告的 RA 疾病活动的一个有价值的工具.
- FLARE-RA得分与基于医生的评估和其他关键的RA结果相关.
- FLARE- RA可用于常规护理和远程监测RA患者.
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