神经元进化的一般原理揭示了人类加速的神经元类型,可能是人类自闭症的高流行原因
Alexander L Starr1, Hunter B Fraser1
1Department of Biology, Stanford University, Stanford, CA 94305, USA.
Molecular biology and evolution
|September 4, 2025
概括
丰富的大脑细胞类型的进化速度较慢, 但大量神经元的特定变化加速了进化, 这表明自然选择影响了人类大脑的进化和自闭症的流行.
科学领域:
- 神经科学
- 进化生物学
- 基因组学
背景情况:
- 多细胞生物表现出由单个基因组编码的多种细胞类型.
- 进化保护在细胞类型之间有很大差异,特别是在哺乳动物的大脑中.
- 影响神经元细胞类型的不同进化速率的因素在很大程度上是未知的.
研究的目的:
- 测试神经元类型丰富与进化约束相关的假设.
- 研究人类新皮层神经元的进化轨迹.
- 探索神经元进化,基因表达和自闭症易感性之间的关系.
主要方法:
- 来自哺乳动物新皮层的跨物种单核RNA测序数据的分析.
- 对不同神经元亚型的基因表达保护的量化.
- 对人类与其他猿类神经元进化的比较分析,重点关注2/3层刺激神经元.
主要成果:
- 在多个数据集和物种中发现了神经元亚型丰度和进化率之间的一致反向关系.
- 层2/3的脑内激发神经元是最多的新皮层类型,在人类中表现出加速的进化.
- 人类神经元的加速进化与多基因阳性选择驱动的自闭症相关基因下调有关.
结论:
- 神经元的丰富性是进化约束的一个关键因素,更高的丰富性导致更大的保护.
- 人类血统在丰富的新皮质神经元中经历了快速进化, 这与自闭症相关基因的表达减少有关.
- 自然选择可能有利于在丰富的神经元中减少某些基因的表达,这可能会增加人类的自闭症风险.
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