相关实验视频

Updated: Sep 9, 2025

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

在乳头甲状腺癌之后的CLIPPERS综合征

Giorgi Mamardashvili¹, Nazibrola Botchorishvili^2,3, Irma Berishvili⁴

¹Department of Neurology, Tbilisi State Medical University, Tbilisi, Georgia.

BMJ case reports

|September 4, 2025

概括

慢性淋巴细胞炎症与对类固醇有反应 (CLIPPERS) 可能与癌症有关. 在癌症治疗之前,期间或之后, 强调持续监测.

科学领域:

神经学
癌症学
免疫学

背景情况:

慢性淋巴细胞炎症 (CLIPPERS) 是一种罕见的脑干炎症综合征.
CLIPPERS的特点是特定的MRI发现和对皮质类固醇的反应.
新出现的证据表明CLIPPERS与癌症相关的免疫反应之间存在潜在的联系.

研究的目的:

报告CLIPPERS与皮质甲状腺癌 (PTC) 的第一次关联.
为了说明CLIPPERS,癌症活动和治疗反应之间的复杂关系.
强调彻底查和长期监测CLIPPERS病例的重要性.

主要方法:

一个中年妇女有神经症状的病例报告.
磁共振成像 (MRI) 用于点脑小细胞增强.
诊断恶性瘤,包括乳头甲状腺癌 (PTC).
通过手术治疗,使用皮质类固醇 (静脉注射甲基普雷尼索隆) 和随访监测 (超声波,甲状腺蛋白水平).

主要成果:

患者表现为面部麻木和心动,MRI显示了CLIPPERS.
被诊断为乳头甲状腺癌 (PTC),并通过甲状腺切除术治疗,导致最初的症状消失.
神经症状复发,重复的MRI显示了CLIPPERS模式,这种模式在皮质类固醇治疗下消失,独立于PTC复发.

结论:

在癌症治疗之前,同时出现或在癌症治疗后复发时,Clippers可以独立于活跃的癌症.
这一案例强调了对CLIPPERS患者进行全面癌症查的必要性.
长期的瘤监测对于治疗CLIPPERS患者和潜在的恶性瘤至关重要.

关键词:

大脑干/小脑磁共振成像技术神经成像

更多相关视频

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Gasless Endoscopic Thyroidectomy via the Trans-Axillary Approach

Published on: September 15, 2023

相关概念视频

The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

The Parathyroid Glands

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...

Synthesis and Regulation of Thyroid Hormones

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...