无症状患者的孕激素诱导的肝损伤
Tarini Prasad Dandasena1, Vaibhav Ingle2, M Sukumar3
1Department of Medical Gastroenterology, All India Institute of Medical Science - Bhopal, Bhopal, MP, India drtariniprasad11@gmail.com.
BMJ case reports
|September 4, 2025
概括
诺瑞可以引起罕见的肝损伤,如中年妇女中转氨基酶升高的情况. 停用孕激素导致了迅速的恢复,强调了识别药物诱导的肝病的重要性.
科学领域:
- 肝病学
- 临床药理学
- 药物引起的肝损伤 (DILI)
背景情况:
- 与雌激素相比,孕激素和诺乙与肝脏异常的发生较少.
- 由孕激素引起的肝损伤可以表现为肝细胞或胆固醇损伤,肝炎或鼻腔阻塞综合征.
- 与代谢功能障碍相关的脂肪酸性肝病 (MASLD) 和酒精使用是肝损伤的常见原因,但在这种情况下没有.
研究的目的:
- 报告一种罕见的诺瑞诱导的肝损伤.
- 强调在无法解释的转氨酶升高时考虑药物诱导的肝病的重要性.
- 为突出疑似药物诱导肝损伤的诊断方法.
主要方法:
- 一个40多岁的女性患者的病例报告, 偶尔发现转氨酶水平升高.
- 综合评估以排除肝损伤的其他原因.
- 使用罗塞尔Uclaf因果关系评估方法 (RUCAM) 来评估药物因果关系.
主要成果:
- 患者被诊断为因诺乙引起的肝损伤.
- 在停止服用诺瑞后,观察到转氨酶水平升高的迅速逆转.
- 患者缺乏典型的MASLD或与酒精有关的肝病风险因素.
结论:
- 诺瑞可能是药物诱导的肝损伤的原因,尽管很少发生.
- 及时诊断和停止使用该药物对于有效的治疗和预防病情至关重要.
- 对于治疗肝病的临床医生来说,了解罕见的不良反应至关重要.
相关概念视频
01:20Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
642
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
642
01:26Diseases of the Liver and Gallbladder
957
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
957