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Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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  1. 首页
  2. 至少重要的堪萨斯市心肌病问卷 心力衰竭严重程度的变化
  1. 首页
  2. 至少重要的堪萨斯市心肌病问卷 心力衰竭严重程度的变化

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至少重要的堪萨斯市心肌病问卷 心力衰竭严重程度的变化

John A Spertus1, Philip G Jones1, Javed Butler2

  • 1University of Missouri Healthcare Institute for Innovations in Quality, Kansas City, Missouri, USA; Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.

JACC. Heart failure
|September 4, 2025

在PubMed 上查看摘要

概括
此摘要是机器生成的。

在堪萨斯城心肌病问卷 (KCCQ) 中的5点变化意味着无论患者的基线健康状况如何,对于心力衰竭患者来说存在临床重要差异. 这一发现有助于在试验和实践中解释KCCQ分数.

关键词:
临床试验心脏衰竭结果生活质量统计方法

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科学领域:

  • 心脏病学
  • 临床结果研究
  • 测量健康状况

背景情况:

  • 堪萨斯市心肌病问卷 (KCCQ) 对于评估心力衰竭患者的结果至关重要.
  • 对于不同心力衰竭严重程度的KCCQ评分,临床重要的最小差异 (MCID) 尚未确定.
  • 了解MCID对于解释患者报告的心力衰竭治疗结果至关重要.

研究的目的:

  • 定义KCCQ总结得分 (OSS) 和KCCQ临床总结得分 (CSS) 的MCID.
  • 在基线心力衰竭严重程度范围内评估MCID.
  • 为确定心力衰竭患者临床意义上的变化可靠的值.

主要方法:

  • 心力衰竭的门诊患者在基线和6周后完成了KCCQ.
  • 患者感知到的健康状况变化被评价为15点的利克尔特等级.
  • 基于感知变化的线性回归模型估计了KCCQ得分的MCID.

主要成果:

  • 总共分析了467名心力衰竭患者.
  • 改善的MCID因基线得分而异,而恶化的MCID则保持不变.
  • 改善或恶化的KCCQ- OSS总体MCID为3. 9分,KCCQ- CSS的结果类似.

结论:

  • 对于心力衰竭患者来说,KCCQ评分的5分变化代表了重要的临床变化.
  • 无论患者的基线健康状况如何,这5点的值是适用的.
  • 这些发现支持在试验和实践中使用5点的KCCQ变化作为有意义的临床终点.