加速生物衰老和心血管疾病的发展轨迹:多个国家的分析
Weiling Yang1, Lihui Zhou1, Mengjing Zhu1
1Tianjin Medical University, Tianjin, China.
Heart (British Cardiac Society)
|September 4, 2025
概括
生物衰老的加速预测高血压和心血管疾病的风险更高. 这项研究强调生物年龄是心血管健康进展和死亡的关键因素.
科学领域:
- 老年学和心血管科学
- 老化的生物标志物
- 公共卫生和流行病学
背景情况:
- 加快的生物衰老与高血压和心血管疾病的风险增加有关.
- 从健康到HTN,心血管疾病和生物衰老影响的死亡率的动态进展需要进一步研究.
- 了解疾病中介状态在这些转变中的作用至关重要.
研究的目的:
- 研究加速生物衰老对健康,高血压,心血管疾病和死亡率之间的转变的影响.
- 使用表型年龄 (PhenoAge) 和Klemera-Doubal方法生物年龄 (KDM-BA) 来评估生物衰老.
- 评估中期疾病在心血管健康进展中的作用.
主要方法:
- 对136,614名英国生物库参与者的分析,最初没有HTN和CVD.
- 使用PhenoAge和KDM-BA进行加速生物衰老的评估.
- 应用多状态模型和调解分析来评估疾病进展途径.
主要成果:
- 加快的生物衰老 (PhenoAge和KDM- BA) 显著增加了发展HTN和心血管疾病的风险.
- 较高的生物年龄加速与从HTN转变为心血管疾病的风险增加有关.
- 加快的生物衰老是健康,高血压和心血管疾病死亡率的重要预测因素,中间疾病起到了关键的作用.
结论:
- 加速的生物衰老是心血管健康轨迹的强有力的预测因素.
- 生物衰老措施为预测心血管衰老和识别有风险的个体提供了框架.
- 这些发现支持通过针对生物衰老的临床下心脏病预防的早期干预策略.
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