对评估 3R/4R Tau PET 图像的敏感视觉读取算法的评估
Ruben Smith1,2, Valentina Garibotto3,4,5, Douglas Hägerström6
1Clinical Memory Research Unit, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden; ruben.smith@med.lu.se.
概括
在PET扫描中,BioFINDER视觉读取 (BF-VR) 算法准确地检测出与阿尔茨海默病相关的tau,其表现优于脑内皮层中的[18F]flortaucipir视觉读取 (FTP-VR). 在临床使用中,BF-VR也表现出了卓越的可靠性.
科学领域:
- 神经成像
- 阿尔茨海默病的诊断方法
- 放射性药物成像技术
背景情况:
- 在临床试验和实践中,精确评估与阿尔茨海默病 (AD) 相关的tau在tau正子发射断层扫描 (PET) 图像中至关重要.
- 目前正在开发视觉读取算法来解释tau PET扫描,需要对定量测量和生物标志物进行验证.
研究的目的:
- 为了比较两种视觉读取算法 (BioFINDER视觉读取[BF-VR]和[18F]flortaucipir视觉读取[FTP-VR]) 的图像精度.
- 将这些算法与半定量测量和酸217 (p-tau217) 状态进行评估.
- 评估BF-VR算法的可靠性.
主要方法:
- 来自BioFINDER-2队列的1654名参与者接受了[18F]RO948PET扫描;37名参与者也接受了[18F]flortaucipir扫描.
- 使用BF-VR协议和已建立的FTP-VR方法分析PET扫描.
- 进行的比较分析包括内皮层 (ERC) 和内元区域的半定量SUV比率 (SUVRs),以及血p-tau217状态.
主要成果:
- 这两种视觉读取方法与半定量SUVR有很强的一致性.
- 与FTP-VR (89.9%) 相比,BF-VR在ERC中显示出较高的tau精度.
- BF-VR表现出优异的interrater (κ=0.87) 和intrarater (κ=0.94) 可靠性,在[18F]RO948和[18F]flortaucipir评估之间具有很高的一致性 (κ=0.94).
结论:
- 视觉读取提供了一种简单的方法来评估tauPET扫描.
- BF-VR算法比FTP-VR更准确地检测ERC中的tau吸收.
- BF-VR显示出卓越的可靠性和与不同的TAU-PET标记剂 ([18F]RO948和[18F]flortaucipir) 相比的性能.
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