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线粒体诊断显示老年小鼠骨肌肉能量的扩散性损伤

Keon D Wimberly¹, Mia Y Kawaida¹, Abigail L Tice¹

¹Department of Applied Physiology and Kinesiology, The University of Florida, Gainesville, FL, USA.

Journal of applied physiology (Bethesda, Md. : 1985)

|September 4, 2025

概括

老化显著损害了小鼠的骨肌肉功能和线粒体能量生产. 这项研究揭示了老化如何影响线粒体的性别差异,突出了潜在的干预目标.

科学领域:

老年学
线粒体生物学
骨肌肉生理学

背景情况:

衰老导致骨肌肉质量,强度和耐力下降,通常与线粒体功能障碍有关.
对肌肉中与年龄相关的线粒体损伤的全面了解仍然不完整.

研究的目的:

研究生物性和衰老对骨肌肉功能和线粒体能量传导的影响.
描述线粒体呼吸,氧化还原和膜潜力的年龄相关变化.

主要方法:

在16个月和26个月的男性和女性C57BL/6小鼠中评估身体功能,肌肉收缩性,组织学和线粒体生物能学.
使用分离的四肢肌肉线粒体,以诊断不同能量需求下的呼吸,氧化还原和膜潜力.

主要成果:

与年轻小鼠 (16-mo) 相比,老小鼠的握力,步行速度和耐力显著下降.
线粒体诊断显示老鼠的氧气消耗率降低了30-50%,呼吸效率降低,不论性别.
观察到性别特异性缺陷:老年男性的碳水化合物基质损伤更大,而老年女性的脂肪酸基质损伤更大.

结论:

老龄化导致骨肌肉线粒体能量传导在雄性和雌性小鼠中的广泛损害.
线粒体诊断为与年龄相关的肌肉线粒体变化提供了新的见解.
这种方法可能有助于确定在衰老过程中维护线粒体健康的干预措施.

关键词:

年龄增长代谢过程线粒体肌肉

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