妊娠糖尿病检测门和12-18个月的婴儿生长,营养和神经发育:随机试验中的前性队列研究
Francesca Amitrano1, Komal Manerkar1, Jane M Alsweiler2,3
1Liggins Institute, University of Auckland, Auckland, New Zealand.
概括
妊娠糖尿病 (GDM) 检测门影响婴儿的结果. 经过治疗的GDM或未经治疗的GDM通过较低的标准检测并没有增加婴儿肥胖或认知问题的风险.
科学领域:
- 产科和妇科
- 儿童营养
- 儿童发育医学
背景情况:
- 孕期糖尿病会影响母亲和婴儿的健康.
- 最佳的GDM检测值也在讨论中.
- 对婴儿发育的影响需要进一步研究.
研究的目的:
- 评估不同GDM检测值如何影响婴儿的生长,营养和神经发育.
- 根据不同的诊断标准和治疗状态,比较暴露于GDM的婴儿之间的结果.
主要方法:
- 在GEMS试验中的前性队列研究.
- 孕妇被随机分为较低或较高的GDM血糖标准.
- 在12-18个月评估婴儿结果:超重/快速增加,食欲,能量摄入,认知能力.
主要成果:
- 暴露于高标准的GDM或低标准的未经治疗的GDM的婴儿体重增加速度较慢,能量摄入量可能较低.
- 没有观察到婴儿食欲或认知分数的显著差异.
- 接受治疗的婴儿GDM (下面的标准) 与对照组相似.
结论:
- GDM检测门和治疗影响婴儿生长轨迹.
- 没有治疗的GDM和未治疗的GDM都通过较低的标准检测出婴儿肥胖风险因素或不良认知结果.
- 这些发现表明GDM诊断标准会影响婴儿的代谢和发育轨迹.
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