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维尼克脑病症:综合分析

Cécile Gras¹, Victoria De Wit², Nacima Oussedik³

¹Centre Régional de Pharmacovigilance, Service de Pharmacologie périnatale, pédiatrique et adulte, Hopital Cochin, Assistance Publique-Hopitaux de Paris (AP-HP), Paris, France. cecile.gras@aphp.fr.

European journal of clinical nutrition

|September 4, 2025

概括

葡萄糖类-1受体激活剂 (GLP- 1 RAs) 可能会增加维尼克脑病的风险,特别是用于肥胖症的较高剂量. 这种神经疾病与吐和食物摄入量减少有关,因此需要进一步进行安全评估.

科学领域:

神经科学
内分泌学
药理学

背景情况:

葡萄糖类-1受体激动剂 (GLP-1RA) 广泛用于糖尿病治疗.
最近对肥胖的批准涉及更高的剂量,需要更新安全性评估.
这些较高剂量的神经风险需要彻底调查.

研究的目的:

评估GLP-1RA与韦尼克脑病变之间的潜在关联.
分析与此不良事件有关的报告病例和安全数据库信息.
在肥胖症中增加GLP-1RA使用的背景下评估风险信号.

主要方法:

一名患有韦尼克脑病症的患者接受了西马格卢提德治疗.
系统的文献审查和世卫组织全球安全数据库 (VigiBase) 对GLP-1 RA相关的韦尼克脑病变病例的分析.
在VigiBase中报告不良事件的不成比例分析.

主要成果:

在治疗肥胖症的患者中观察到Wernicke脑病变,与吐和摄入量减少有关.
在文献和VigiBase中发现了另外18个病例.
在68%的病例中报告了恶心,吐或减少食物摄入量,并显著减肥.
不成比例的分析表明,对于半谷氨酸,化和GLP- 1 RAs来说,报告的维尼克脑病率更高.

结论:

对于GLP-1RA存在威尼克脑病的潜在安全信号,特别是用于肥胖症的高剂量.
与胃肠道副作用 (如吐和摄入量减少) 的关联值得注意.
由于这些药物的使用日益扩大,建议进一步及时评估和临床警.

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