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睡眠时间和上皮卵巢癌的风险
Flavie Marquis1,2, Jennifer A Ritonja3,4, Geneviève Gariépy2
1Université de Montréal Hospital Research Centre (CRCHUM), Montreal, QC, Canada.
Cancer causes & control : CCC
|September 4, 2025
概括
成年人每晚睡眠时间超过7-9小时可能会增加患卵巢癌的风险. 这项研究发现睡眠时间较长与各种卵巢癌相关的风险较高.
科学领域:
- 流行病学
- 癌症学
- 睡眠医学
背景情况:
- 睡眠时间是可以改变的行为,
- 之前的研究表明, 睡眠模式可能与癌症发展有关.
- 卵巢上皮癌 (EOC) 的风险因素尚未完全理解,因此需要进一步研究生活方式的相关性.
研究的目的:
- 研究成年人睡眠时间与上皮卵巢癌风险之间的关联.
- 研究睡眠时间与不同卵巢癌行为 (侵袭性与边缘性) 的关系.
- 探索睡眠时间与特定的侵袭性卵巢癌亚型 (I型 vs. 一种类型的II).
主要方法:
- 一个基于人群的病例对照研究,涉及465例卵巢癌和855例对照.
- 从20岁开始,评估成年人平均睡眠时间.
- 使用无条件多变量和多组逻辑回归模型进行统计分析.
主要成果:
- 与7-9小时相比,每晚睡眠时间超过9小时与卵巢癌的风险增加有关 (OR,1. 78;95% CI,1. 15-2. 75).
- 在侵袭性和边缘性卵巢瘤中观察到这种风险增加.
- 较长的睡眠时间 (> 9 小时) 也与I型和II型侵袭性卵巢癌亚型的风险增加有关.
结论:
- 睡眠时间超过每晚7-9小时的成年人可能面临更高的卵巢癌风险.
- 睡眠时间似乎是不同卵巢癌分类的相关因素.
- 需要进一步研究睡眠模式和卵巢癌的病因.
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