在水性深层乳液溶剂系统中研究ibuprofen和empagliflozin的溶解:实验和热力学建模见解
Shadi Janfaza1, Ali Haghtalab2
1Department of Processing, Faculty of Chemical Engineering, Tarbiat Modares University, P.O. Box 14115-143, Tehran, Iran.
Pharmaceutical research
|September 4, 2025
概括
这项研究探讨了用于改善易溶性药物如伊布洛芬和恩帕格利夫洛辛溶解的深溶性溶剂 (DES). 较高的DES度和温度显著提高了药物的溶性,UNIQUAC模型准确地预测了这些效应.
科学领域:
- 制药科学
- 物理化学
- 材料科学
背景情况:
- 水溶性较差的药物存在重大制剂挑战,限制了生物可用性.
- 深度乙溶剂 (DES) 为药物溶解提供了可调和环保的替代品.
- 了解药物溶剂相互作用对于开发有效的药物输送系统至关重要.
研究的目的:
- 评估由四基 (TBPB) 和二甲基醇 (DEG) 组成的新型深溶解剂 (DES) 在增强ibuprofen (IBU) 和empagliflozin (EMPA) 溶解方面的有效性.
- 研究不同DES度和温度对药物的溶解性和溶解动力学的影响.
- 使用热力学模型进行预测准确度的实验溶解度数据的相关性.
主要方法:
- 从四基化物 (TBPB) 和乙烯基醇 (DEG) 合成一个DES.
- 在11个质量分数和温度 (20-40°C) 中测量IBU和EMPA在水溶液中的表面溶解度.
- 使用威尔逊,NRTL和UNIQUAC热力学模型监测24小时的溶解动力学和数据的相关性.
主要成果:
- 布洛芬和empagliflozin都在DES水系统中溶解得更快,而布洛芬的溶解度更高.
- 药物溶解度随着更高的DES度和升高的温度而增加,表明一种内热溶解过程.
- UNIQUAC热力学模型在与实验溶解数据的相关性方面表现出最好的准确性.
结论:
- 基于TBPB-DEG的DES有效地提高了水溶性较差的药物,如伊布洛芬和恩帕格利夫洛辛的溶解性和溶解性.
- 温度和DES度是影响药物溶解的关键参数,观察到正相关性.
- 热力学建模,特别是UNIQUAC模型,对于预测和理解DES系统中的药物溶解度是有价值的.
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