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通过FOXM1介导的细胞循环调节恢复口腔上皮质平衡

Yuan Wang¹, Yimeng Cai¹, Qi Yin¹

¹State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.

Science China. Life sciences

|September 4, 2025

概括

通过增强细胞增殖和原沉积,αKG加速口腔伤口的愈合. 这种代谢物通过FOXM1介导的细胞循环调节恢复口腔上皮质平衡,为组织修复提供治疗潜力.

科学领域:

生物医学
复原医学
口腔生物学

背景情况:

在口腔内粘膜损伤需要快速修复口腔上皮质平衡.
甲基酸 (αKG) 是一种代谢物,在蛋白质合成,表观遗传学和免疫反应中发挥作用,这表明它有可能在组织修复中发挥作用.

研究的目的:

调查阿尔法基酸盐 (αKG) 在加速口腔伤口愈合方面的治疗潜力.
阐明αKG促进口腔上皮细胞修复的分子机制.

主要方法:

在体内给予αKG以加快口腔伤口愈合.
使用表皮细胞中的Ki67和EDU标记物的细胞增殖评估.
细胞循环相关途径的分析,包括CDK1-cyclin复合体和FOXM1表达.
开发聚乙烯胺 (PEI) /聚烯酸 (PAA) /αKG超分子网络,以优化本地传递.

主要成果:

αKG的使用显著加快了口腔伤口的愈合,并改善了表皮再形成和原沉积.
通过更高的Ki67和EDU标记,αKG增加了上皮细胞的增殖.
αKG上调细胞循环通路,特别是调节CDK1- 环素A/ B活性和促进FOXM1的表达.
该PEI/PAA/αKG超分子网络显示出增强本地交付的潜力.

结论:

通过增强上皮细胞增殖和原合成,αKG有效促进口腔伤口愈合.
αKG的治疗作用通过FOXM1依赖的细胞循环进展调节.
αKG是恢复口腔表皮平衡并促进口腔伤口修复的有前途的治疗剂.

关键词:

其他类型阿尔法基酸盐细胞周期口腔上皮质平衡

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