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Updated: Sep 9, 2025

Synergetic Use of Neural Precursor Cells and Self-assembling Peptides in Experimental Cervical Spinal Cord Injury
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带正电荷的聚氨支架重塑微环境,促进脑损伤后的内生再生

Jingjing Lin1, Yushui He1, Mofei Yuan2

  • 1College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Med-X Center of Materials, Sichuan University, Chengdu 610065, China.

Biomacromolecules
|September 4, 2025
PubMed
概括

带正电荷的支架通过清除损伤相关的分子模式 (DAMPs) 来减少炎症并促进创伤性脑损伤 (TBI) 后的大脑修复. 具有阴性脊柱的支架表现出优异的结果,突出显示了它们对中枢神经系统 (CNS) 再生的潜力.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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