甲状腺敏感度指数与新诊断的中年和老年2型糖尿病患者甲状腺功能正常之间的相关性
Lixuan Fang1,2, Cuiping Lin3, Lijuan Gu4
1Department of Endocrinology and Metabolism, Jiangxi Medical College, The Second Affiliated Hospital, Nanchang University, Nanchang City, 330006, Jiangxi Province, China.
在正常甲状腺功能的2型糖尿病 (T2DM) 患者中,较低的自由三甲状腺素/ 自由甲状腺素 (FT3/ FT4) 比率与骨密度降低有关. 这种比率可以预测这些人的骨质疏松风险.
科学领域:
- 内分泌学
- 代谢疾病
- 骨质新陈代谢
背景情况:
- 2型糖尿病 (T2DM) 与骨质代谢的改变有关.
- 甲状腺激素对骨健康起着至关重要的作用.
- 在甲状腺功能正常的T2DM患者中,甲状腺激素敏感性与骨健康之间的关系需要进一步研究.
研究的目的:
- 检查甲状腺激素敏感度指数与骨代谢标志物之间的关联.
- 在新诊断的中年和老年T2DM患者中发现低骨质量和骨质疏松症的预测因子.
- 评估FT3/FT4比对该群体骨健康的作用.
主要方法:
- 350名新诊断的甲状腺功能正常的T2DM患者 (≥45岁) 的回顾性分析.
- 基于骨矿物密度的分层 (正常与低骨质量/骨质疏松症).
- 测量甲状腺激素 (FT3,FT4,TSH),骨标记 (OC,BALP,Ca,P) 和其他临床参数;计算甲状腺敏感度指数 (FT3/FT4比率等). ) 的情况.
主要成果:
- 患有低骨质量/ 骨质疏松症的患者FT3/ FT4比率较低,骨质卡素 (OC) 和高密度脂蛋白胆固醇 (HDL- C) 增加.
- FT3/ FT4比率与OC,骨特异性酸酶 (BALP) 和 (Ca) 水平有积极的相关性.
- 较低的FT3/ FT4比率被确定为低骨质量和骨质疏松症的重要风险因素,特别是在HbA1c≥7%的患者中.
结论:
- 反映了外围甲状腺激素敏感性的FT3/ FT4比率与T2DM患者的骨代谢标志物有显著关联.
- 在该群体中,FT3/FT4比率降低可能会增加低骨质量和骨质疏松症的风险.
- 在正常甲状腺功能的T2DM患者中,FT3/FT4比率显示为早期查工具和骨质疏松症预测剂的潜力.
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