在兽医环境和狗患者中调查抗瘤药物表面污染
Andrew Floeder1, Jingfang Huang2, Kelly Bergsrud3
1Division of Environmental Health Sciences, School of Public Health, University of Minnesota Twin Cities, Minneapolis, MN 55455, United States.
Annals of work exposures and health
|September 5, 2025
概括
危险的抗瘤药物可以污染瘤诊所和家庭的表面. 一种新的LC-SRM-MS/MS方法可以检测表面和物上的药物残留物,帮助评估暴露风险.
科学领域:
- 分析化学
- 环境科学
- 职业健康问题
背景情况:
- 抗瘤药物在医疗保健环境中存在暴露风险.
- 化疗剂的表面污染是医护人员和护理人员的关注点.
- 对于在表面同时检测多种抗瘤药物的方法是有限的.
研究的目的:
- 开发和验证一种敏感的LC-SRM-MS/MS方法来检测六种抗药物.
- 在兽医瘤诊所量化环胺和多克索鲁比辛的表面污染.
- 研究狗患者将抗瘤药物污染转移到家庭环境中的可能性.
主要方法:
- 开发了一种液体色谱选择反应监测质谱法 (LC-SRM-MS/MS).
- 优化了药物回收的表面擦拭和脱吸技术 (49%-79%).
- 从兽医诊所的治疗区域,犬舍和犬病患者的表面擦拭样本进行分析.
主要成果:
- 通过LC-SRM-MS/MS方法实现了较低的检测极限 (0.01-0.12 ng/ml).
- 在临床表面检测到环胺和多克索鲁比辛 (6. 68-40. 3 pg cm-2).
- 在狗患者和家庭环境中发现药物残留物,表明家庭污染的可能性.
结论:
- 经过验证的LC-SRM-MS/MS方法有效检测出抗瘤药物污染.
- 这些发现突显了兽医诊所的风险和物传播到家庭的可能性.
- 这种方法可以为减少对化疗药物的职业和环境暴露提供信息.
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