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在慢性非特异性部疼痛患者中,手动治疗可减少疼痛,残疾和氧化应激;双盲随机试验
Betsos Theodoros1, Zemadanis Konstantinos1, Papadea Polyxeni2
1Physiology Laboratory, Faculty of Medical School, National and Kapodistrian University of Athens, Athens, Greece.
The Journal of manual & manipulative therapy
|September 5, 2025
概括
手动治疗 (MT) 在慢性非特异性部疼痛 (CNNP) 患者中显著减少疼痛,残疾和氧化应激 (OS). 这项研究表明,MT可以使血清脂质过氧化物 (LOOH) 水平升高正常化,与假干预不同.
科学领域:
- 生物医学科学
- 整形医学
- 治疗疼痛
背景情况:
- 慢性非特异性部疼痛 (CNNP) 影响全球数以百万计的人,
- 氧化应激 (OS) 涉及到CNNP,但其与手动治疗 (MT) 的关系,是一种常见的治疗方法,尚未得到充分研究.
研究的目的:
- 调查低速度低幅度 (LVLA) 和高速度高幅度 (HVLA) MT对CNNP患者的疼痛,残疾和OS的影响.
- 将MT与虚假干预在控制CNNP症状和生物标志物的有效性进行比较.
主要方法:
- 使用双盲随机试验设计.
- 氧化应激通过血清脂质过氧化物 (LOOH) 来测量.
- 使用数字疼痛评分表 (NPRS) 和部残疾指数 (NDI) 评估疼痛和残疾.
主要成果:
- 在CNNP患者中,MT显著降低了血清LOOH水平,使其正常化至健康个体的水平.
- 接受MT治疗的患者的NPRS和NDI得分显著降低,表明疼痛和残疾减少.
- 假干预组在LOOH,NPRS或NDI得分上没有显著改善.
结论:
- 在CNNP患者中有效降低疼痛和残疾.
- 在CNNP患者中,MT还显著降低了OS水平,这表明与缓解疼痛有机械联系.
- OS评估可以帮助评估MT在CNNP疼痛管理中的有效性.
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