在1期临床试验中为患有晚期癌症的人提供缓解护理:范围审查
Diego Candelmi1,2,3, Alazne Belar2,3, Carla Zapata Del Mar1,4
1Palliative Medicine Department, Clínica Universidad de Navarra, Pamplona, Spain.
Palliative medicine
|September 5, 2025
概括
第一阶段的癌症试验提供了先进的治疗方法,但需要综合性息治疗. 这篇评论强调了患者的需求和整合挑战,呼吁在瘤学试验中提供专门的息治疗.
科学领域:
- 癌症学
- 缓和护理
- 临床试验研究
背景情况:
- 第1期癌症临床试验为没有对标准治疗反应的晚期癌症提供了新的治疗方法.
- 这些试验中的患者有显著的缓解护理需求,由于与实验治疗的潜在目标冲突,这些需求往往未得到满足.
- 生活质量是息护理的一个关键问题,在侵袭性癌症治疗的背景下可能会被误解.
研究的目的:
- 系统地审查和绘制有关癌症第一阶段临床试验中的息护理和整合的现有文献.
- 确定接受实验性癌症治疗的患者的缓解护理方面的知识差距.
- 在早期瘤学试验中优化息治疗的未来研究方向.
主要方法:
- 采用了系统范围审查方法.
- 在多个数据库 (PubMed, Web of Science, Scopus, CINAHL, PsycINFO, Google Scholar) 进行了搜索,寻找2003年至2023年间发表的研究.
- 这项审查重点关注了参与1期临床试验的晚期癌症患者.
主要成果:
- 其中包括50项研究, 显示患者的预期寿命有限, 症状重重, 痛苦, 精神需求未得到满足.
- 患者对预后信息和临终讨论表示不情愿,阻碍了事先的护理计划.
- 终身护理的特点是经常住院,住院死亡和延迟住院转诊;护理人员经历了痛苦,医疗保健专业人员遇到了整合障碍.
结论:
- 该审查强调了癌症临床试验第一阶段患者和护理人员的独特需求.
- 将专门的息治疗纳入瘤学试验具有复杂性,需要进一步调查.
- 未来的研究应优先制定标准化指导方针,以在临床试验单位内整合息治疗.
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