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美国的适用性和可预防的心血管疾病事件
Hridhay Karthikeyan1, Wenjun Fan1,2, Nathan D Wong1,2
1Mary and Steve Wen Cardiovascular Division, School of Medicine, University of California, Irvine, CA, USA.
Diabetes & vascular disease research
|September 5, 2025
概括
在符合条件的美国2型糖尿病 (T2DM) 患者中,赛马格卢提德每年可预防超过75,000例心血管疾病 (CVD). 这凸显了赛马格卢提德在治疗T2DM和降低心血管疾病风险方面的显著潜力.
科学领域:
- 心脏病学
- 内分泌学
- 公共卫生
背景情况:
- 在SUSTAIN-6试验中,在2型糖尿病 (T2DM) 患者中,塞马格卢提德对心血管疾病 (CVD) 的益处得到了证明.
- 估计塞马格卢提德对美国人口的影响需要评估适用性和潜在的心血管疾病事件减少.
研究的目的:
- 根据SUSTAIN-6的标准,估计美国有T2DM的成年人有资格接受西马格卢提德的数量.
- 量化每年可预防的心血管疾病事件和相关并发症的数量.
主要方法:
- 使用了美国T2DM成年人的国家健康和营养检查调查 (2011-2020年) 的数据.
- 应用SUSTAIN-6资格标准来确定符合条件的人群.
- 使用SUSTAIN-6试验和权重人口数据的已公布事件率计算可预防的CVD事件.
主要成果:
- 在美国,有690万患有T2DM的成年人有资格接受西马格卢提德.
- 估计每年可能预防75,681次主要结局心血管疾病事件.
- 预计每年预防128,329例复合心血管疾病事件,72,390例主要不良心血管事件和75,681例病例.
结论:
- 在符合条件的美国T2DM成年人中,塞马格卢提德有可能预防大量心血管事件.
- 在符合条件的T2DM患者中增加塞马格卢提德的使用可能会显著降低心血管疾病的负担.
- 需要进一步努力,以改善T2DM患者获得和使用这些有益的疗法.
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