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Updated: Sep 9, 2025

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血管NOTCH3沉积负荷:与NOTCH3基因型和CADASIL疾病严重程度的关联

Yu-Wen Cheng1, Chih-Hao Chen1, Chi-Chao Chao1

  • 1Department of Neurology, National Taiwan University Hospital, Taipei.

Neurology. Genetics
|September 5, 2025
PubMed
概括

在CADASIL中,NOTCH3变异基因型显著影响了血管NOTCH3细胞外域 (NOTCH3ECD) 沉积. 较高的NOTCH3ECD负载与大脑微型血液的增加相关,但并非整体疾病的严重程度.

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