血清尿酸与高密度脂蛋白胆固醇的比例与老年人中风有关:一项基于人群的研究
Qingsong Jiang1, Guoyong Zhan1, Yi Liu2
1Department of Neurosurgery, QuZhou KeCheng People's Hospital, Quzhou, China.
Frontiers in neurology
|September 5, 2025
概括
尿酸与高脂胆固醇的比率 (UHR) 与老年人中风风险的增加有关. 升高的UHR表明氧化应激和代谢功能障碍增加,突出显示其作为预测标志物的潜力.
科学领域:
- 心血管研究
- 代谢健康
- 老年医学
背景情况:
- 氧化应激和代谢障碍是心血管疾病的关键因素.
- 尿酸与高密度脂蛋白胆固醇的比率 (UHR) 是这些疾病的新兴标志物.
- 了解UHR在中风风险中的作用对于老年人群的预防策略至关重要.
研究的目的:
- 研究尿酸与高密度脂蛋白胆固醇 (UHR) 之间的关系和中风风险.
- 分析美国老年人口中的这种关系.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) (1999-2018) 的横截面数据.
- 包括16562名年龄在60岁及以上的参与者.
- 使用后勤回归,限制立方线,子组分析和ROC曲线进行统计分析.
主要成果:
- 较高的UHR水平与中风病例的比例增加相关.
- 在调整后,最高UHR四分位数的个体的中风风险增加了1. 48倍 (OR: 1. 23-1. 80).
- 与单个尿酸或HDL- c水平相比,UHR对中风的预测值更高.
结论:
- 在老年人中,UHR升高与中风风险显著增加有关.
- 在非糖尿病患者中,这种关联似乎更强烈.
- 需要进一步的大规模前性研究来证实这些发现并探索临床影响.
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