Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

863
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
863
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

1.9K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.9K
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

15
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
15
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

1.3K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.3K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

38
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
38
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

537
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
537
这页已由机器翻译。其他页面可能仍然显示为英文。View in English
  1. 首页
  2. 研究领域
  3. 生物医学和临床科学
  4. 免疫学
  5. 自体免疫性
  6. 类药物相关的死性自身免疫性肌病:揭示类药物再暴露后的抗体阳性疾病
  1. 首页
  2. 研究领域
  3. 生物医学和临床科学
  4. 免疫学
  5. 自体免疫性
  6. 类药物相关的死性自身免疫性肌病:揭示类药物再暴露后的抗体阳性疾病

相关实验视频

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.0K

类药物相关的死性自身免疫性肌病:揭示类药物再暴露后的抗体阳性疾病

Aurora Cafuli1, Anthony Martins2, Nosagie Ohonba1

  • 1Internal Medicine, Overlook Medical Center, Summit, USA.

Cureus
|September 5, 2025

在PubMed 上查看摘要

概括
此摘要是机器生成的。

重新暴露于他类药物可能会引发或恶化死体自身免疫性肌肉病 (NAM),这是一种炎症性肌肉疾病,特别是在具有潜在HMGCR抗体的患者中. 早期诊断和治疗对于防止永久性肌肉损伤至关重要.

关键词:
抗hMgcr抗体肌酸激酶的升高免疫介导的肌肉炎免疫抑制疗法

更多相关视频

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.1K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

13.5K

相关实验视频

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model
07:35

Aggravation of Myocardial Ischemia upon Particulate Matter Exposure in Atherosclerosis Animal Model

Published on: December 10, 2021

2.0K
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.1K
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
08:45

LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring

Published on: November 17, 2018

13.5K

科学领域:

  • 神经学
  • 免疫学
  • 药理学

背景情况:

  • 死亡性自身免疫性肌肉病 (NAM) 是一种罕见的炎症性肌肉病,其特征是肌肉逐渐衰弱和肌肉激酶 (CK) 升高.
  • 静止剂药物可能与NAM的发展有关,特别是在特定的自身抗体的存在下.
  • 亚临床NAM可能会被揭露或加剧.

研究的目的:

  • 报告一个经过他类药物再暴露而被揭露的死亡性自身免疫性肌肉病 (NAM).
  • 突出了与他类药物相关的诊断挑战和临床表现.
  • 强调在接受他类药物治疗的患者中早期识别和治疗NAM的重要性.

主要方法:

  • 一位65岁的男性在恢复他类药物治疗后出现了不明原因的肌肉衰弱.
  • 诊断工作包括肌酸激酶 (CK) 水平,肝酶评估,3- 基-3- 甲基氨酸减少酶抗体 (HMGCR Ab) 测试,磁共振成像 (MRI) 和肌肉活检.
  • 分析了临床表现,诊断结果和治疗反应.

主要成果:

  • 患者在重新接受他类药物后出现了无痛的靠近肌肉衰弱和升高的CK水平.
  • 诊断测试显示出阳性HMGCR Ab,MRI结果与炎症性肌肉病相一致,肌肉活检显示出免疫媒介性瘤性肌肉病 (IMNM) 的特征.
死亡性自身免疫性肌肉病
靠近肌肉的软弱
药物重启使用
类他类药物诱导的自身免疫性结核性肌病
类他类药物诱导的肌肉病
类固醇节约剂
  • 最初的症状是微妙的,肝酶升高最初被误认为是肝硬化.
  • 结论:

    • 在敏感个体中,特别是具有HMGCR抗体的个体中,重新暴露可能会导致NAM或恶化.
    • 临床医生应考虑在接受他类药物治疗的患者中出现不明原因的肌肉衰弱或肝酶升高.
    • 及时诊断和启动免疫抑制疗法对于改善结果和预防不可逆转的肌肉损伤至关重要.