作为口腔状细胞癌的初始治疗最佳支持性护理的回顾性研究
Yuko Saito1, Hideaki Hirai1, Ryota Kobayashi1
1Division of Oral and Maxillofacial Surgery, Faculty of Dentistry and Graduate School of Medical and Dental Sciences, Niigata University, Niigata, JPN.
Cureus
|September 5, 2025
概括
年长的口腔状细胞癌患者通常选择最佳支持性治疗 (BSC) 由于晚期和较低的白蛋白水平. 这些因素对BSC的决定有很大影响,强调了早期诊断和个性化护理计划的必要性.
科学领域:
- 癌症学
- 临床医学
- 癌症研究
背景情况:
- 口腔状细胞癌 (OSCC) 患者可以选择最佳支持性治疗 (BSC) 而不是积极治疗.
- 有限的数据比较了选择BSC与标准治疗的OSCC患者的临床特征.
研究的目的:
- 追溯分析选择初始BSC和接受标准治疗的OSCC患者的临床特征差异.
- 确定影响OSCC患者选择BSC的因素.
主要方法:
- 对135名OSCC患者的初级病历进行了回顾性分析 (2018-2023年).
- 人口统计数据,瘤特征,ECOG-PS,并发症,NLR,白蛋白水平,生活状况和生存率 (OS,DSS) 的比较.
- 统计分析包括t测试,奇方测试,卡普兰-梅尔,日志等级测试和多重后勤回归.
主要成果:
- BSC患者年龄较大 (平均年龄为84岁相比为67.4岁),女性患病率较高,白蛋白水平较低 (p<0.001).
- 晚期分类 (III/ IV) 和更高的ECOG- PS (2- 4) 与BSC有显著的相关性 (p< 0. 001).
- 与非BSC组 (97.2%和97.2%) 相比,BSC组的一年OS和DSS率明显较低.
结论:
- 年龄,晚期分类和低白蛋白水平是选择OSCC患者,包括75岁及以上患者的关键预测因素.
- 早期诊断和干预对于改善治疗机会至关重要.
- 为了确保接受BSC的患者有尊严的终身护理, 合作护理计划是必不可少的.
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