使用区域均性和基于种子的功能连接方法研究2型糖尿病对阻塞性睡眠呼吸暂停患者的大脑功能的影响
Wang Zhezi1, Xiong Yanxi1, Xie Xingwu1
1Department of Radiology Imaging Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Frontiers in neuroscience
|September 5, 2025
概括
2型糖尿病 (T2DM) 在阻塞性睡眠呼吸暂停 (OSA) 患者中恶化脑功能,影响认知能力. 这项研究使用神经成像揭示T2DM
科学领域:
- 神经科学
- 医学成像
- 内分泌学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与认知障碍有关.
- 2型糖尿病 (T2DM) 可能进一步影响OSA患者的脑功能.
研究的目的:
- 研究T2DM对OSA患者大脑功能的影响.
- 使用区域同质性 (ReHo) 和功能连接性 (FC) 分析.
- 探索临床数据和神经成像发现之间的关系.
主要方法:
- 招募了46名OSA,38名OSA+T2DM和34名健康对照 (HC).
- 收集临床数据并进行神经心理测试 (MoCA,MMSE,ESS).
- 获得的静止状态fMRI数据用于ReHo和基于种子的FC分析.
主要成果:
- 与HC相比,OSA患者在特定的大脑区域呈现了改变的ReHo和降低的FC.
- 在OSA患者中,T2DM导致左椎 ReHo减小,并改变了与丘脑的FC.
- 与临床变量相关的成像指标包括ODI,MMSE,IRI和HbA1c.
结论:
- 在OSA患者中,T2DM会加剧认知负担.
- 这些发现提供了对T2DM在OSA中的神经病理机制的见解.
- 支持在OSA中开发T2DM的客观神经成像生物标志物.
相关概念视频
Sleep Apnea
218
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
218
Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K


