从自我报告的命中量来估计大麻的消费量
Mohammad I Habib1, Alan J Budney1, Cara A Struble1
1Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College.
Cannabis (Albuquerque, N.M.)
|September 5, 2025
概括
通过考虑多个命中尺寸 (MQHS) 而不是单个命中尺寸 (SHS) 来估计大麻功效 (mgTHC). 这种方法更好地反映了个体大麻使用的变化,以获得更准确的delta-9四大麻醇测量.
科学领域:
- 大麻研究
- 药理学
- 公共卫生
背景情况:
- 精确估计delta-9四大麻素 (mgTHC) 对于了解大麻消费至关重要.
- 之前的方法依赖于单击大小 (SHS),可能导致不准确的mgTHC计算.
- 在SHS方法中不考虑大麻"击中"大小的个体变化.
研究的目的:
- 调查多次定性命中大小 (MQHS) 方法来估计mgTHC.
- 通过MQHS与SHS得出的mgTHC估计值进行比较.
- 评估自我报告的命中量 (小,中,大) 对大麻功效计算的影响.
主要方法:
- 调查了1824名成年大麻使用者,
- 使用SHS和MQHS方法计算mgTHC.
- 对于花和缩剂的不同击中大小 (小,中,大) 确定每击的克比 (GPHR).
主要成果:
- 对于大麻花,MQHS的估计值高于SHS的估计值.
- 对于大麻缩剂,MQHS估计在所有被击中大小中都高于SHS.
- 花的中位数GPHR因受伤大小而有显著变化,但对缩物则表现出地板效应.
结论:
- 使用MQHS方法可以更好地估计mgTHC的含量,因为它考虑了击大小的变化,特别是对于花.
- 由于观察到的地板效应,需要进一步研究以完善大麻缩物的MQHS估计.
- MQHS为制定标准化GPHR提供了一个框架,以量身定制的质量测试规模类别.
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