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介质细胞结构细胞2.0:超越常规

Gabrielle A Mandl1, Malak Lahrichi2, Perla Matar3

  • 1Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada.

Frontiers in immunology
|September 5, 2025
PubMed
概括

介质细胞 (MSC) 可以被重新编程为抗原呈现细胞 (APC) 用于癌症疫苗. 这些MSC-APC在控制瘤方面表现有前途,并为癌症免疫治疗提供了一个新的平台.

关键词:
抗原呈现细胞癌症免疫疗法介质层细胞疫苗的使用

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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