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Updated: Jun 16, 2026

A Quantitative Dot Blot Assay for AAV Titration and Its Use for Functional Assessment of the Adeno-associated Virus Assembly-activating Proteins
14:49

A Quantitative Dot Blot Assay for AAV Titration and Its Use for Functional Assessment of the Adeno-associated Virus Assembly-activating Proteins

Published on: June 12, 2018

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CoreTIA:用于AAV中和的模块化,统计学上可靠的转导抑制试验

Beatrix Kovács1,2,3, Fanni Somogyi1,2, Viktória Szabó4

  • 1Institute of Cognitive Neuroscience and Psychology, HUN-REN Research Centre for Natural Sciences, Budapest, Hungary.

Frontiers in immunology
|September 5, 2025
PubMed
概括

一种新的测试,核心转导抑制测试 (coreTIA),标准化了腺相关病毒 (AAV) 中和抗体 (NAb) 的检测. 这种方法提供了精确的位数和量化的不确定性,提高了基因疗法研究的一致性.

关键词:
AAV 中和抗体AAV 血清型优化贝叶斯剂量反应模型不确定性的ND50量化测试协调和标准化基因疗法的免疫性中和抗体标位在实践中进行同等性测试

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Author Spotlight: Improved Method for Production and Purification of Adeno-Associated Viral Vectors09:12

Author Spotlight: Improved Method for Production and Purification of Adeno-Associated Viral Vectors

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