微生物群在与炎症相关的精神疾病中的作用
Liying Zhou1, Qunhua Wu2, Lin Jiang2
1Department of Obstetrics and Gynecology, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Frontiers in immunology
|September 5, 2025
概括
肠道微生物群影响大脑健康, 通过免疫系统途径影响精神疾病. 针对肠道微生物的疗法通过调节神经炎症来治疗这些疾病.
科学领域:
- 神经免疫学
- 微生物组研究
- 精神遗传学
背景情况:
- 肠-大脑轴连接肠道微生物群和中枢神经系统 (CNS) 的功能.
- 肠道微生物及其代谢物调解神经免疫反应.
- 失调与精神疾病如抑郁症,焦虑症和精神分裂症有关.
研究的目的:
- 审查肠道微生物群在与炎症有关的精神疾病中的作用.
- 强调神经免疫交叉和神经递质合成的微生物调节.
- 评估微生物代谢物在精神疾病中的作用.
主要方法:
- 目前证据的文献综合.
- 专注于神经炎症和神经递质的微生物调节.
- 评估微生物代谢物,如SCFA和氨酸衍生物.
主要成果:
- 来自肠道的促炎细胞因子 (例如IL-6,TNF-α) 可以到达中枢神经系统,激活小质细胞.
- 微质过度活化和神经炎症与严重抑郁症,焦虑症,自闭症和精神分裂症有关.
- 针对微生物群的疗法 (益生菌,FMT) 通过恢复平衡和减少炎症显示出潜力.
结论:
- 肠道微生物通过神经免疫路径对精神疾病产生重大影响.
- 微生物代谢物在精神疾病中起着双重作用.
- 肠-大脑轴的精确调节提供了管理精神疾病的框架.
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