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在艾滋病毒治愈试验中,肠道微生物群,血代谢和大脑功能之间的相互作用

Alessandra Borgognone¹, Anna Prats^2,3, Ashish Arunkumar Sharma⁴

¹IrsiCaixa, Badalona, Spain.

Frontiers in cellular and infection microbiology

|September 5, 2025

概括

肠道细菌及其代谢物与艾滋病毒感染者的神经认知障碍 (PWH) 有关. 本研究探讨了这些联系,在HIV治疗策略试验中确定了HIV相关神经认知障碍 (HAND) 的潜在生物标志物.

科学领域:

微生物组研究
神经科学
病毒学

背景情况:

肠道微生物组合与艾滋病毒感染者的神经认知障碍有关.
在艾滋病毒治愈策略的背景下,肠道微生物,代谢物和神经认知之间的相互作用尚未得到充分理解.
在治疗中断期间,BCN02试验研究了罗米德素 (RMD) 和MVA.HIVconsv疫苗.

研究的目的:

分析 BCN02 试验中的纵向肠道微生物组,血代谢组和大脑功能数据.
确定与艾滋病毒相关的神经认知障碍 (HAND) 的潜在关联和新生物标志物.
探索PWH中的微生物和代谢特征与认知功能之间的关系.

主要方法:

便中遗传学和血代谢组分析.
在18名参与者中进行认知 (NPZ-6),功能和神经成像评估.
在RMD注射前后对微生物,代谢物和组合指数进行纵向评估.

主要成果:

神经认知障碍 (较低的NPZ-6) 与特定的细菌 (例如Desulfovibrio desulfuricans) 和1,2-propanediol降解途径有关.
多种组分分析显示了微生物特征,脂质代谢途径和神经认知障碍之间的相关性.
差异性指数与功能性结果呈负相关性,与介入前的神经精神症状呈正相关性.

结论:

这些发现加强了肠道细菌,代谢物和PWH神经认知功能之间的联系.
这项研究为发现HAND的预测生物标志物提供了分析框架.
需要进一步的验证研究来证实干预对观察到的轮班的直接影响.

关键词:

艾滋病毒代谢组微生物组神经认知疫苗试验

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