术前布德索尼德对术后喉疼痛的影响:系统性审查和元分析
Helal Metwalli1,2, Mohammad Najm Dadam2,3, Gam Hong Pham4
1Faculty of Human Medicine, Benha University, Benha, Egypt.
Hospital pharmacy
|September 5, 2025
概括
在手术前使用布德索尼德有效降低手术后喉痛 (POST) 的发生率和严重程度. 这种抗炎药物提供了一种可行的,具有成本效益的选择,用于在内内输管后预防POST.
科学领域:
- 麻醉学
- 药理学
- 呼吸系统医学
背景情况:
- 手术后喉疼痛 (POST) 是内管道输液后的一个常见并发症.
- 一种抗炎性皮质类固醇Budesonide正在研究POST预防.
研究的目的:
- 评估布德索尼德在减少POST的发生率和严重性的有效性.
- 将布德索尼德与安慰剂,无干预药物和其他药物进行比较.
主要方法:
- 在PubMed,Scopus,Web of Science和Cochrane图书馆的系统文献搜索中遵循PRISMA指南.
- 使用随机或固定效应模型对POST发病率进行元分析.
- 对POST严重性的顺序逻辑回归分析,比较布德索尼德与盐水.
主要成果:
- 与安慰剂相比,Budesonide显著降低了POST发生率,并且没有干预 (P < .001).
- 布德索尼德的疗效与硫酸和胺相似.
- 布德塞尼德降低了POST的严重程度,增加了轻度病例,降低了中度/重度病例 (OR0. 46).
- 与布德塞尼德和德克萨米松联合治疗的疗效优于单独使用布德塞尼德.
结论:
- 在手术前使用布德索尼德是一种有效的预防药物,可减少POST的发生率和严重程度.
- 它的局部抗炎作用,成本效益和安全性支持临床使用.
- 需要进行进一步的RCT来标准化用于POST预防的budesonide剂量和施用方案.
相关概念视频
01:23Chronic Pharyngitis
4.8K
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
4.8K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
382
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
382
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
425
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
425
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
374
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
374
01:26COPD: Management Using Bronchodilators and Corticosteroids
300
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
300
01:26Tonsillitis II: Management
172
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
172