相关实验视频
Updated: Sep 9, 2025
13:00
Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
2.4K
对VYD222的结构和功能分析:一种针对SARS-CoV-2变体的广泛中和抗体
bioRxiv : the preprint server for biology
|September 5, 2025
概括
一种新的抗体VYD222 (pemivibart) 有效地中和了包括Omicron KP.3在内的SARS-CoV-2变种. 它的广泛疗效源于独特的结合部位,为抗击不断演变的COVID-19菌株提供了希望.
科学领域:
- 病毒学
- 免疫学
- 结构生物学
背景情况:
- SARS-CoV-2 尖端蛋白突变降低了现有的单克隆抗体 (mAbs) 的有效性.
- 需要广泛中和抗体来对抗不断演变的SARS-CoV-2变种.
研究的目的:
- 为了描述VYD222 (pemivibart),一个由ADG20 (adintrevimab) 衍生而来的重新设计的人类mAb.
- 评估VYD222对广泛的SARS-CoV-2变种的中和作用.
- 为了阐明VYD222广泛和强大的活动的结构基础.
主要方法:
- 用X射线结晶学来确定VYD222与SARS-CoV-2受体结合域的复合结构.
- 深度突变扫描以识别影响VYD222中和的SARS-CoV-2突变.
- 针对各种SARS-CoV-2变种的体外中和试验.
主要成果:
- VYD222对包括Omicron KP.3和KP.3.1.1在内的多种SARS-CoV-2变体具有强大的中和作用.
- 结构分析显示VYD222的表位跨越受体结合部位到CR3022部位,解释了其广泛的活性.
- 由于结构上的限制和维护病毒受体结合的必要性,SARS-CoV-2 从VYD222中逃脱是有限的.
结论:
- VYD222 (pemivibart) 是一种高效的,对广泛的SARS-CoV-2变异抗体的抗体.
- 抗体的独特结合方式提供了对病毒进化的强有力的防御.
- 这些发现支持VYD222对COVID-19预防的有用性,并为未来的抗体开发和变种风险评估提供了见解.
更多相关视频
相关概念视频
01:10Antibody Structure
61.2K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
61.2K
02:50Conjugated Proteins
18.5K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.5K