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Updated: May 7, 2026

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基于结构的虚拟查识别了增强微细胞的TREM2向小分子

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    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
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    研究人员发现了一种新型小分子EN020, 这种TREM2调节器有望开发新的阿尔茨海默病治疗方法,为基于抗体的治疗提供替代方案.

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    Calmodulin-dependent Signaling01:16

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    Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
    The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...