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Updated: May 6, 2026

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
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使用pMHC伪型病毒和酵母显示器对TCR抗原接口进行深度映射

Stephanie A Gaglione, Jonathan Krog, Frances R Keer

    bioRxiv : the preprint server for biology
    |September 5, 2025
    PubMed
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    一种新的方法VelociRAPTR快速选数以百万计的T细胞受体 (TCR) 与抗原的相互作用. 它映射了TCR序列如何影响抗原识别,帮助T细胞治疗的发展和预测非目标效应.

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    Antigens Involved in Adaptive Immunity

    An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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